Selected Publications

2026

Elucidating molecular regulatory rules of nanoparticle biological identity via standardized deep proteomics
Chao Jiang#, Haozhe Huang#,*, Rongzi Gao, Yuling Du, Baichuan Jin, Wenwei Li, Mengjie Wang, Yunlu Dai, Yuan Liu*.
PNAS, Accepted.
Non-genetic engineering nanozyme proximity labeling reveals subcellular in situ interactomes and trafficking pathways of nanoparticles
Chao Jiang, Yiyang Fu, Baichuan Jin, Rongzi Gao, Wenwei Li, Ze Wang, Haozhe Huang, Zirui Zhuang, Yunlu Dai*, Ji Jing*,Yuan Liu*.
PNAS, 2026, Vol. 123, e2521555123.
Personalized Protein Aptamer Corona Enables Sensitive and Multiplexed Low-Abundance Serum Protein Detection via DNA Nanomachine-Enhanced MALDI-TOF
Jinlong Fan, Lichao Wang, Yue Sun, Baichuan Jin, Enyu Wang, Yingying Ding, Jincao Yao, Guangming Huang, Dong Xu*, and Yuan Liu*.
Chemical Engineering Journal, 2026, 175115.
Aptamer-Mediated Protein Corona In Situ Multiplex Microfluidic Detection for Cancer Diagnosis
Weizhao Yao#, Yaru Li#, Yuling Du, Rongzi Gao, Junhao Tan, Jinlong Fan*, and Yuan Liu*.
Analytical Chemistry, 2026, 98, 7123−7135.

2025

Evolution of Multivalent Aptamer Corona for High-Throughput Multiplexed Multi-Cancer Diagnosis
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan*, and Yuan Liu*.
Advanced Science, 2025, e14976:1-13.
Transforming Nanoproteomics into Multidimensional Raman Spectromics for Ovarian Cancer Diagnosis
Xin Dai#, Qimanguli Saiding#, Haoxiang Guo, Baichuan Jin, Qiqi Liu, Mengjie Wang, Jinlong Fan, Haobing Guo, Jianqing Zhu, Wei Tao*, and Yuan Liu*.
Cell Biomaterials, 2025, 2(2), 100275.
Personalized Cancer-Specific Protein-Aptamer Corona for Orthogonal Multiplex Cancer Diagnosis
Jinlong Fan, Baichuan Jin, Xin Dai, Ting Fu, Lu Sun, Guangyi Jiang, Weishan Lu, Qixun Chen, Liu Yang*, Jiangqing Zhu*, Yuan Liu*, and Weihong Tan*.
Journal of the American Chemical Society, 2025, 147(44):40664-40675.
Triglyceride-Rich Conditions Reshape the Protein Corona and Alter Nano-Bio Interactions
Ali Arbab#, Mengjie Wang#, Haoxiang Guo, Chao Jiang, Ze Wang, Xin Dai, Yunfeng Zong, and Yuan Liu*.
ACS Applied Materials & Interfaces, 2025, 17(39):54608-54622.
Nanoparticle–Protein Corona Boosted Cancer Diagnosis with Proteomic Transfer Learning
Haoxiang Guo#, Baichuan Jin#, Zhenjie Zhu#, Xin Dai, Mengjie Wang, Yueli Xie, Chenlu Xu, Zongping Wang, Yuan Liu*, and Weihong Tan*.
ACS Nano, 2025, 19(26):23592-23605.
Aptamer-Signatured Nanoparticle Protein Corona for Size-Dependent Fluorescent Barcoding Diagnosis
Yue Sun, Jinlong Fan, Yunfeng Zong, Baichuan Jin, Weizhao Yao, Ze Wang, Ting Fu, Luo Fang*, Yuan Liu*, and Weihong Tan*.
Small, 2025, 21(26):2410434.
Extreme Tolerance of Nanoparticle Protein Corona to Ultra-High Abundance Proteins Enhances the Depth of Serum Proteomics
Qiqi Liu#, Mengjie Wang#, Xin Dai, Shuangqin Li, Haoxiang Guo, Haozhe Huang, Yueli Xie, Chenlu Xu, Yuan Liu*, Weihong Tan.
Advanced Science, 2025, 12(11):2413713.

2024

A Robust ROS Generation and Ferroptotic Lipid Modulation Nanosystem for Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy
Chao Jiang, Wenxi Li, Jie Yan, Xinying Yu, Yuzhao Feng, Bei Li, Yuan Liu*, and Yunlu Dai*.
Advanced Healthcare Materials, 2024, 13(30):2401502.
Protein Denaturation for In-Depth Serum Proteome Profiling and Enhanced Cancer Diagnosis
Yueli Xie#, Mengjie Wang#, Haoxiang Guo, Baichuan Jin, Chenlu Xu, Xin Dai, Yiyang Fu, Ze Wang, Weizhao Yao, Yuan Liu*, Weihong Tan*.
Nano Today, 2024, 59:102488.
Nanoparticle–Protein Corona-Based Tissue Proteomics for the Aging Mouse Proteome Atlas
Lichao Wang, Xu Yang, Yueli Xie, Chenlu Xu, Xin Dai, Mengjie Wang, Yuan Liu*.
Analytical Chemistry, 2024, 96(36):14363-14371.
Proteome Fishing for CRISPR/Cas12a-Based Orthogonal Multiplex Aptamer Sensing
Shuangqin Li, Baichuan Jin, Yintao Ma, Xu Yang, Jinlong Fan, Yueli Xie, Chenlu Xu, Xin Dai, Mengjie Wang, Qiqi Liu, Ting Fu, Yuan Liu*, Weihong Tan*.
Journal of the American Chemical Society, 2024, 146(29):19874-19885.
Serum Protein Fishing for Machine Learning-Boosted Diagnostic Classification of Small Nodules of Lung
Mengjie Wang#, Xin Dai#, Xu Yang, Baichuan Jin, Yueli Xie, Chenlu Xu, Qiqi Liu, Lichao Wang, Lisha Ying, Weishan Lu, Qixun Chen, Ting Fu, Dan Su*, Yuan Liu*, and Weihong Tan*.
ACS Nano, 2024, 18(5):4038-4055.

2023

Recent Progress of Aptamer–Drug Conjugates in Cancer Therapy
Jiaxuan He, Qiao Duan, Chunyan Ran, Ting Fu, Yuan Liu*, Weihong Tan*.
Acta Pharmaceutica Sinica B, 2023, 13(4):1358-1370.

Before Hangzhou Institute of Medicine Chinese Academy of Sciences

Nano-bio interactions in cancer: from therapeutics delivery to early detection
Yuan Liu, Junqing Wang, Qingqing Xiong, Daniel Hornburg, Wei Tao, Omid C. Farokhzad.
Accounts of Chemical Research, 2021, 54(2), 291-301.
Macrophage-targeted gene therapy to improve the atherosclerotic plaque stability
Yuan Liu, Xiaoyuan Chen.
Matter, 2020, 3(3), 621-622.
Ostwald ripening-mediated grafting of metal-organic frameworks on a single colloidal nanocrystal to form uniform and controllable MXF
Yuan Liu, Yu Yang, Yujia Sun, Jibin Song, Nicholas G. Rudawski, Xiaoyuan Chen, Weihong Tan.
Journal of the American Chemical Society, 2019, 141(18), 7407-7413.
In situ polymerization on nanoscale metal-organic frameworks for enhanced physiological stability and stimuli-responsive intracellular drug delivery
Yuan Liu, Christina Gong, Yunlu Dai, Zhen Yang, Guocan Yu, Yijing Liu, Mingru Zhang, Lisen Lin, Wei Tang, Zijian Zhou, Guizhi Zhu, Jiji Chen, Orit Jacobson, Dale Kiesewetter, Zhantong Wang, Xiaoyuan Chen.
Biomaterials, 2019, 218, 119365.
Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy
Yuan Liu, Christina Gong, Lisen Lin, Zijian Zhou, Yijing Liu, Zhen Yang, Zheyu Shen, Guocan Yu, Zhantong Wang, Sheng Wang, Ying Ma, Wenpei Fan, Liangcan He, Gang Niu, Yunlu Dai, Xiaoyuan Chen.
Theranostics, 2019, 9(10), 2791-2799.
Bioengineering of Metal-organic Frameworks for Nanomedicine
Yuan Liu, Yanli Zhao, Xiaoyuan Chen.
Theranostics, 2019, 9(11), 3122-3133.
ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy
Yuan Liu, Weijia Hou, Lian Xia, Cheng Cui, Shuo Wan, Ying Jiang, Yu Yang, Qiong Wu, Liping Qiu, Weihong Tan.
Chemical Science, 2018, 9(38), 7505-7509.
Chelation-assisted assembly of multidentate colloidal nanoparticles into metal-organic nanoparticles
Yuan Liu, Hao Sun, Lu Yang, Xiaochen Zhu, Xirui Wang, Jiamin Liang, Xiaowei Li, Ying Jiang, Weijia Hou, Caue Favero Ferreira, Daniel R. Talham, Arthur F. Hebard, Weihong Tan.
Nanoscale, 2018, 10(45), 21369-21373.
Aptamer-based multifunctional ligand-modified UCNPs for targeted PDT and bioimaging
Weijia Hou#, Yuan Liu#, Ying Jiang, Yuan Wu, Cheng Cui, Yanyue Wang, Liqin Zhang, I-Ting Teng, Weihong Tan.
Nanoscale, 2018, 10(23), 10986-10990.
Thiol-ene click chemistry for orthogonal bioconjugation of colloidal nanoparticles
Yuan Liu, Weijia Hou, Hao Sun, Cheng Cui, Liqin Zhang, Ying Jiang, Yongxiang Wu, Juan Li, Brent Sumerlin, Qiaoling Liu, Weihong Tan.
Chemical Science, 2017, 8(9), 6182-6187.
Ionic functionalization of hydrophobic colloidal nanoparticles to form ionic nanoparticles with enzymelike properties
Yuan Liu, Daniel L. Purich, Cuichen Wu, Yuan Wu, Tao Chen, Cheng Cui, Liqin Zhang, Sena Cansiz, Weijia Hou, Yanyue Wang, Shengyuan Yang, Weihong Tan.
Journal of the American Chemical Society, 2015, 137(47), 14952-14958.
Facile surface functionalization of hydrophobic magnetic nanoparticles
Yuan Liu, Tao Chen, Cuichen Wu, Liping Qiu, Rong Hu, Juan Li, Liqin Zhang, Cheng Cui, Guizhi Zhu, Mingxu You, Tao Zhang, Weihong Tan.
Journal of the American Chemical Society, 2014, 136(36), 12552-12555.
Higher visible photocatalytic activities of nitrogen doped In2TiO5 sensitized by carbon nitride
Yuan Liu, Gang Chen, Chao Zhou, Yidong Hu, Dingguo Fu, Jie Liu, Qun Wang.
Journal of Hazardous Materials, 2011, 190(1-3), 75-80.